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KMID : 0378019750180070879
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New Medical Journal
1975 Volume.18 No. 7 p.879 ~ p.890
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Histopathological Changes in Lymphoid Organs during Growth of Ehrlich Carcinoma
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Abstract
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A gravimetric and histopathologic study of lymph node, spleen and thymus changes associated with growth of transplanted Ehrlich carcinoma in mice was carried out to understand the immunological mechanisms during the growth of tumor. The tumor induced vigorous histological response in the regional and nonregional lymph nodes and spleen, whereas no significant histological response was identified in thymus. The early response evident at 7 days after tumor grafting was confined to the paracortical area of lymph node and periarterial lymphatic sheath of spleen, which was characterized by pronounced increase in numbers of large pyroninophilic cells and moderate increase in content of lymphocytes. By day 14, plasmacytosis in medulla of lymph node and marginal zone of spleen and active germinal centers were apparent besides continued presence of large pyroninophilic cells in paracortical area of lymph node and periarterial lymphatic sheath of spleen. During the later stages of the tumor growth, the early response, which was similar to that usually associated with cell-mediated immune mechanism, disappeared but plasmacytosis and prominent germinal centers, which were possibly related to the humoral immune mechanism, remained active.
It is suggested that failure of rejection of the tumor may be possibly due to specific defect existing in the lymphoid organs. The plasmacytosis suggests that plasma cells develop in response to the tumor and are producing antibody, possibly "blocking" antibody.
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